Type III-A CRISPR immunity promotes mutagenesis of staphylococci

Type III-A CRISPR immunity promotes mutagenesis of staphylococci

Nature, Published online: 07 April 2021; doi:10.1038/s41586-021-03440-3

In Staphylococcus epidermidis and Staphylococcus aureus, non-specific DNase activity of the type III-A CRISPR–Cas system increases the rate of mutations in the host and accelerates the evolution of resistance to antibiotics and to phage.Type III-A CRISPR immunity promotes mutagenesis of staphylococci
Source: Nature