Tumoural activation of TLR3–SLIT2 axis in endothelium drives metastasis

Tumoural activation of TLR3–SLIT2 axis in endothelium drives metastasis

Nature, Published online: 30 September 2020; doi:10.1038/s41586-020-2774-y

Expression of the axon-guidance gene Slit2 in endothelium, induced by endothelial sensing of tumour-derived double-stranded RNA, promotes metastatic dissemination in mouse models of breast and lung cancer.
Source: Nature