Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Nature, Published online: 21 July 2021; doi:10.1038/s41586-021-03752-4

Single-cell RNA sequencing and T cell receptor sequencing are combined to identify transcriptional programs specific to mutation-associated neoantigen-specific T cells in non-small cell lung cancers treated with anti-PD-1, providing insights into resistance to PD-1 blockade.Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
Source: Nature