Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer

Nature, Published online: 09 September 2020; doi:10.1038/s41586-020-2690-1

TRIM37 overexpression promotes centrosome dysfunction that drives genomic instability in breast cancer cell lines containing the recurrent 17q23 amplicon, revealing a vulnerability that can be targeted to eliminate cancer cells.
Source: Nature