Systems-level effects of allosteric perturbations to a model molecular switch

Systems-level effects of allosteric perturbations to a model molecular switch

Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03982-6

Interface mutations in the GTPase switch protein Gsp1 (the yeast homologue of human RAN) allosterically affect the kinetics of the switch cycle, revealing a systems-level mechanism of multi-specificity.
Source: Nature