Structure of human Ca<sub>v</sub>2.2 channel blocked by the painkiller ziconotide

Structure of human Ca<sub>v</sub>2.2 channel blocked by the painkiller ziconotide

Nature, Published online: 07 July 2021; doi:10.1038/s41586-021-03699-6

Cryo-electron microscopy structures of human Cav2.2 in the presence or absence of ziconotide reveal the molecular basis of the specificity of this painkiller for Cav2.2, and provide insights into electromechanical coupling in Cav channels.Structure of human Ca<sub>v</sub>2.2 channel blocked by the painkiller ziconotide
Source: Nature