Structural basis of cytokine-mediated activation of ALK family receptors

Structural basis of cytokine-mediated activation of ALK family receptors

Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03959-5

Structural studies of the complex of anaplastic lymphoma kinase and leukocyte tyrosine kinase and their activating cytokines identify unique architectural features of the complex, and provide a novel mechanistic paradigm among receptor tyrosine kinases.
Source: Nature