Shared structural mechanisms of general anaesthetics and benzodiazepines

Shared structural mechanisms of general anaesthetics and benzodiazepines

Nature, Published online: 02 September 2020; doi:10.1038/s41586-020-2654-5

Cryo-electron microscopy structures of GABAA receptors bound to intravenous anaesthetics and benzodiazepines reveal both common and distinct transmembrane binding sites, and show that the mechanisms of action of anaesthetics partially overlap with those of benzodiazepines.
Source: Nature