Senolytic CAR T cells reverse senescence-associated pathologies

Senolytic CAR T cells reverse senescence-associated pathologies

Nature, Published online: 17 June 2020; doi:10.1038/s41586-020-2403-9

Chimeric antigen receptor (CAR) T cells targeting uPAR, a cell-surface protein that is upregulated on senescent cells, eliminate senescent cells in vitro and in vivo and reduce liver fibrosis in mice.
Source: Nature