Oncometabolites suppress DNA repair by disrupting local chromatin signalling

Oncometabolites suppress DNA repair by disrupting local chromatin signalling

Nature, Published online: 03 June 2020; doi:10.1038/s41586-020-2363-0

Metabolites that are elevated in tumours inhibit the lysine demethylase KDM4B, resulting in aberrant hypermethylation of histone 3 lysine 9 and decreased homology-dependent DNA repair.
Source: Nature

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