Mutant clones in normal epithelium outcompete and eliminate emerging tumours

Mutant clones in normal epithelium outcompete and eliminate emerging tumours

Nature, Published online: 13 October 2021; doi:10.1038/s41586-021-03965-7

The rarity of tumour formation despite the high proportion of cancer-driver mutations in epithelia is explained by the competitive fitness of tumour cells relative to that of surrounding mutant epithelial cells.
Source: Nature