Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

Nature, Published online: 15 February 2021; doi:10.1038/s41586-020-03045-2

The tumour microenvironment is low in glucose and high in the alternative metabolite lactate, which regulatory T cells are shown here to use, maintaining their ability to suppress effector immune cells.Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
Source: Nature