Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition

Nature, Published online: 12 May 2021; doi:10.1038/s41586-021-03540-0

Analyses of hippocampal AMPA receptor–auxiliary subunit complexes provide insights into the predominant assemblies and organization of the AMPA receptor, TARP-γ8 and CNIH2/SynDIG4 and explain the mechanism of inhibition of a clinically relevant, brain-region-specific allosteric inhibitor.Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition
Source: Nature