Heterotypic cell–cell communication regulates glandular stem cell multipotency

Heterotypic cell–cell communication regulates glandular stem cell multipotency

Nature, Published online: 26 August 2020; doi:10.1038/s41586-020-2632-y

The multipotency of basal stem cells is directly regulated by luminal cells through the secretion of TNF, and, following luminal cell ablation, the Notch, Wnt and EGFR signalling pathways reactivate basal cell multipotency.
Source: Nature