Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis

Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis

Nature, Published online: 11 November 2020; doi:10.1038/s41586-020-2928-y

mTORC1 stabilizes HMG-CoA reductase, a rate-limiting enzyme in the cholesterol biosynthesis pathway, via the deubiquitylase USP20 in response to feeding.
Source: Nature