Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

Nature, Published online: 16 September 2020; doi:10.1038/s41586-020-2725-7

The PARP2–HPF1 histone-modifying complex bridges two nucleosomes to align broken DNA ends for ligation, initiating conformational changes that activate PARP2 and enable DNA damage repair.
Source: Nature