A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

Nature, Published online: 01 July 2020; doi:10.1038/s41586-020-2444-0

Dysregulation of an mTORC1 substrate-specific mechanism leads to constitutive activation of TFEB, and promotes kidney cystogenesis and tumorigenesis in a mouse model of Birt–Hogg–Dubé syndrome.
Source: Nature