A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Nature, Published online: 06 October 2021; doi:10.1038/s41586-021-03990-6

The small molecule JNJ-A07 interferes with the interaction between the NS3 and NS4B proteins of dengue virus and reduces the viral load in mice even when first administered at peak viraemia.
Source: Nature