A condensate-hardening drug blocks RSV replication in vivo

A condensate-hardening drug blocks RSV replication in vivo

Nature, Published online: 07 July 2021; doi:10.1038/s41586-021-03703-z

Cyclopamine and its chemical analogue A3E inhibit replication of human respiratory syncytial virus (RSV) by hardening the liquid–liquid phase-separated inclusion bodies, resulting in the inhibition of virus replication in the lungs of RSV-infected mice.A condensate-hardening drug blocks RSV replication in vivo
Source: Nature